Dr. Montgomery is an associate professor of surgery, director of the incompatible kidney transplant program, chief of the division of transplantation, and director of the Comprehensive Transplant Center at the Johns Hopkins University and Hospital. He received his medical education at the University of Rochester, where he was the valedictorian of his class. He received his Ph.D. at the University of Oxford, England, in molecular immunology. Montgomery completed his general surgical and multi-organ transplantation training at Johns Hopkins Hospital. He was a postdoctoral fellow in human molecular genetics also at Johns Hopkins.

Dr. Montgomery has been involved in the development of innovative approaches to expanding live donor renal transplantation, including: the laparoscopic donor nephrectomy, positive crossmatch and ABO incompatible transplantation, paired kidney exchange, and altruistic donor programs. His work with patients in these programs has been featured on the Today Show, Good Morning America, the CBS and NBC Evening News, CNN, the Discovery Channel, and in USA Today, the New York Times and Washington Post. He was part of the team that performed the world's first live donor kidney removal using minimally invasive techniques. He led the team that performed the first triple-swap kidney transplant. He is considered an expert worldwide on kidney transplantation for highly sensitized and ABO incompatible patients. His other clinical interests include the use of expanded criteria donors and pulsatile perfusion pumping to preserve and rescue these organs. Dr. Montgomery is the principal investigator on a Health and Human Services grant to study methods of optimizing utilization of kidneys from deceased donors.