June 6, 2007 — In a big step toward a long-sought goal, three teams of scientists say they've produced the equivalent of embryonic stem cells, at least in mice, without taking the controversial step of destroying embryos.
Their procedure makes ordinary skin cells behave like stem cells. If the same can be done with human cells — a big if — the procedure could lead to breakthrough medical treatments without the contentious ethical and political debates surrounding the use of embryos.
Embryonic stem cells can give rise to all types of tissue, so experts believe they might be used to create transplant therapies for people who are paralyzed or have ilnesses ranging from diabetes to Parkinson's disease.
To harvest human embryonic stem cells, human embryos have to be destroyed, an action opposed by many people. The new studies are the latest to attempt to avoid embryo destruction.
Scientists have long hoped to find a way to reprogram ordinary body cells to act like stem cells, avoiding the use of embryos altogether. The new mouse studies seem to have accomplished that.
"I think it's one of the most exciting things that has come out about embryonic stem cells, period," said stem cell researcher Dr. Asa Abeliovich of Columbia University in New York, who didn't participate in the work. "It's very convincing that it's real."
But he and others cautioned that it will take further study to see whether this scientific advance can be harnessed for new human therapies.
"We have a long way to go," said John Gearhart of Johns Hopkins University, a stem cell researcher who also wasn't involved in the new work.
In any case, it is crucial that scientists continue research with standard embryonic stem cells, said researcher Konrad Hochedlinger of the Harvard Stem Cell Institute, who led one of the three teams.
He and his colleagues present their work in the inaugural issue of the journal Cell Stem Cell. (The first word in the journal's name refers to its publisher, Cell Press).
The other two teams reported their results Wednesday on the web site of the journal Nature. Rudolf Jaenisch of the Whitehead Institute in Cambridge, Mass., is the senior author of one paper, and the work behind the other paper was led by Shinya Yamanaka of Kyoto University in Japan.
