Glaucoma Drug Makes Eyelashes Longer, Thicker

Eric Bland, Discovery News
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March 18, 2009 -- A drug used to lower eye pressure in glaucoma patients is now being marketed to make eyelashes longer, darker and thicker.

"This is a new innovation for lashes," said Frederick Beddingfield, Chief Medical Officer for Allergan, the company marketing the drug, known as Latisse. "Latisse fulfills a significant and previously unmet aesthetic need in the marketplace."

According to clinical trials conducted by Allergan last year, 278 patients taking Latisse averaged eyelashes that were 25 percent longer, 106 percent thicker and 18 percent darker. That translates into 1.4 millimeters of eyelash growth after 16 weeks of use.

Latisse, also known as bimatoprost, was originally prescribed under the brand name Lumigen to patients with glaucoma, a condition that raises the pressure inside the eye and can cause blindness. Once a day, patients would drip a 0.03-percent bimatoprost solution onto the affected eye.

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The relatively concentrated bimatoprost solution binds to receptors in the eye to lower the pressure inside. The exact mechanism for how bimatoprost increases eyelash length, thickness and darkness is unknown.

Patients and doctors quickly noted a pleasant side effect. According to Quigley, the effect was so dramatic that people could tell the difference from across a room.

But like many drugs, concentrated bimatoprost has some unpleasant side effects as well. The whites of the eyes can become permanently discolored due to an increase in melatonin, a pigment that also helps darken eyelashes. And in some patients, the lash changes soon became unpleasant.


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