Earliest Known Bacterial Infection Found

Rossella Lorenzi, Discovery News
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Ancient Infection
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Aug. 20, 2009 -- The bones of an ancient hominin may hold evidence of the earliest known bacterial infection, according to a team of international researchers who diagnosed the skeleton with a disease called brucellosis.

The discovery of the infection may provide insight into the eating habits of these early human ancestors.

Consisting of eighteen mostly incomplete bones, the skeletal remains were found decades ago in the Sterkfontein caves near Johannesburg, South Africa.

The partial skeleton, known as Stw 431, belonged to an adult individual -- probably a male -- of the late Pliocene hominin species Australopithecus africanus.

Analysis of the 1.5 to 2.5 million-year-old bones showed that two vertebrae were dotted with lesions. A previous study concluded that the damage was caused by trauma.

But Ruggero D'Anastasio, a palaeoanthropologist at the University "Gabriele d'Annunzio" in Chieti, Italy, and colleagues contend that the lesions are the result of an acute inflammatory process rather than a traumatic fracture.

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"After carefully evaluating all reasonable alternative hypotheses, we suggest that the position, gross morphology and the radiological appearance of the lesions... seem to be more consistent with the pathological condition of early brucellosis," the researchers wrote in the journal PLoS ONE.

Brucellosis is a debilitating disease whose symptoms include recurrent fevers, joint pain, weakness and profuse sweating.

Primarily found in animals such as sheep or goats, brucella is often contracted from unpasteurized milk and cheese.

The disease is relatively rare today in developed countries, although it is still present in areas such as North Africa and the Middle East.

"As for this Australopithecus africanus individual, the infective agent could have been Brucella abortus. Zebras, antelopes and other South African fauna can carry this bacterial species, which causes spontaneous abortion," D'Anastasio told Discovery News.

According to the researcher, the hominin may have contracted brucellosis by eating fetal tissue from an infected animal.


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